Archived News & Events
Annual Resident Laparoscopic Training Lab
April 2018 - Stanford, CA
Research Highlights: Active Surveillance
In 2 recent studies published online, Dr. James Brooks and colleagues have analyzed methods to predict which men can safely be followed with active surveillance of low risk prostate cancer. In the first study, they found that the finding on no cancer on follow-up biopsies obtained on men while they were on surveillance predicted a much lower risk that they would need treatment (surgery or radiation therapy) 2 or more years later. In the second study, they found that the rate of change of PSA while on surveillance (up or down) predicted future treatment. In this study, they observed that PSA was highly variable while on surveillance and statisticians at the University of Washington developed a sophisticated method to “smooth out” those fluctuations that improved prediction. In that same study, they found that PSA testing can be safely done every 6 months, rather than more frequently, for men on surveillance.
Urinary obstruction is a common cause of kidney failure and can be challenging to diagnose. Using several models of urinary obstruction, Dr. James Brooks and colleagues identified a set of RNAs that can be measured in the urine that are candidates for predicting permanent kidney damage. These results were recently published online in the American Journal of Physiology-renal Physiology.
Jan 25-26, 2018
Dr. Viraj Master, Professor of Urology at Emory University School of Medicine, was invited to Stanford January 25-26, 2018 as the 21st Fenmore Visiting Professor in Urology. This visiting professorship has a long history at Stanford, and has included in recent years Harry Herr, Pat Walsh, Craig Peters and many others. This year, Dr. Master received the top votes among our faculty and residents for this honor!
Photos from Dr. Master's visit
If you thought infertility was just a female problem, think again. Dr. Michael Eisenberg, director of Male Reproductive Medicine and Surgery at Stanford Healthcare, is quoted in this article from The Guardian on male fertility tests and the advantages of direct-to-consumer testing.
Dr. Ben Chung, associate professor of Urology and senior author on a recent study comparing robotic-assisted and laparoscopic surgeries for kidney removal, shares with The Wall Street Journal that they found the robotic surgeries exceeded 4 hours 46% of the time, compared with 26% of hte time for the laparoscopic procedures. The longer operating time results in a greater cost, as does an extra $985 per surgery for robotic instrumentation supplies.
SUFU Grant Award
Raveen Syan, FPMRS fellow and principal investigator, and faculty mentors Amy Dobberfuhl and Craig Comiter, were awarded a grant from the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction (SUFU) for their 2017 SUFU Foundation Study of Chemodenervation. The project titled "Feasibility and Efficacy of Transvaginal OnabotulinumtoxinA Chemodeneration of the Trigone for the Third Line Treatment of Refractory Overactive Bladder." Congrats, Raveen, Amy, and Craig!
Dr. Michael Eisenberg, director of Male Reproductive Medicine and Surgery at Stanford Healthcare, comments on a new study's findings that ibuprofen, a popular pain medication often popped by men who suffer minor aches and pains related to sports, may be linked to infertility.
Michael Eisenberg and his colleagues found that men who suffer symptoms from varicoceles — a condition affecting an estimated 17 million men living in the U.S. — are more likely to develop vascular and metabolic disease. Their findings were published online Dec. 1 in Andrology. Michael Eisenberg, MD is the senior author. Urology resident Nancy Wang, MD, is the lead author. The research is highlighted here, in articles from Men's Health, Daily Mail, and in a Stanford Medicine press release.
Residency interviews were a success!
Candidates from all over the country traveled to Stanford on 11/17 and 11/28 to interview for a spot in the Urology residency program.
A new study by Kai Dallas and colleagues published online ahead of print in the Journal of Endourology, suggests that greater precipitation, and not just higher temperatures, in a region may place its residents at increase risk of urinary stone disease.
New research by Michael Eisenberg, assistant professor of urology, and urology resident Andrew Sun, suggests that there is a positive correlation between frequency of marijuana use and frequency of sexual intercourse.The research is highlighted here, in articles from CNN, Forbes, Newsweek, HealthDay News, San Jose Mercury News, The Telegraph (U.K.), Vice, and others, and in a Stanford Medicine press release.
A study by Stanford researchers shows that the use of robot-assisted surgery to remove kidneys isn't always more cost-effective than using traditional laparoscopic methods. Senior author Benjamin Chung, associate professor of urology, is quoted in this article. The research is also highlighted on Science News and in a Stanford Medicine press release.
Baby Wren Margaux Kasman has arrived!
Alex and Jessica Kasman welcomed a daughter, Wren Margaux Kasman, on Monday, October 23rd.
Philip Hanno, clinical professor of urology, is one of the authors of a new book coming out next month titled, Insterstitial Cystitis. All proceeds go to the International Association for the Study of Bladder Pain Syndrome (ESSIC). Click here for details on how to order.
New publication accepted in Urology
Craig Stauffer, Chris Elliott and Tin Ngo's recent publication "Is Neurogenic Bladder A Risk Factor for Febrile Urinary Tract Infection After Ureteroscopy and if so, why?" was just accepted for publication in Urology.
The sudden rise in male infertility is a scary national crisis. According to urologist and associate professor Michael Eisenberg, "Here is direct evidence that the function of reproduction is failing. We should try to figure out why that is." What we do know about declining sperm count tells us a great deal about not only reproduction but also the overall health of men - and what it tells us isn't good. Is it simply modern life iteself - obesity, inactivity, stress, close cellphones, even older parenthood that's driving down sperm levels? It's the beginning of an answer but not the full one.
Michael Eisenberg, assistant professor of urology, is the senior researcher on a new study in the journal Human Reproudction, which reports that the average age of today's American dad is roughly 3.5 years older than his counterpart from four decades ago, growing from 27.4 years in 1972 to 30.9 years in 2015. The new study is quickly generating media attention and buzz around the internet:
Looking at the safety of Active Surveillance in monitoring patients with prostate cancer
James Brooks, professor of urology, is part of a team of researchers who received funding from the National Institutes of Health to use natural language processing to mine electronic medical records to identify patients with low risk prostate cancer who are managed by Active Surveillance. In Active Surveillance, men with small, low risk cancers are followed with PSA tests, physical examinations and biopsies with the intention that they switch to either surgery or radiation therapy if their cancer becomes more aggressive. Dr. Brooks is part of a national study of Active Surveillance in which they have found that approximately 2/3 of patients have cancers that do not progress and do not need treatment after 5 years of monitoring. Identifying all patients on Active Surveillance at Stanford and elsewhere will allow Dr. Brooks and colleagues to look at the safety of Active Surveillance, understand variations in care patterns (e.g. how often patients get PSA tests and biopsies) and test whether other tests such as prostate MRI scans are helpful in managing patients.
Last week, a new study revealed an alarming drop in sperm counts for men Western countries. Does this mean men are becoming infertile? According to expert Michael Eisenberg, assistant professor of urology, "it should be seen as a wake-up call, but not necessarily the end of days."
Meet our PGY1 Residents!
2017 Department of Urology Picnic - SCRA
James Brooks, professor of urology, and collaborators from Denmark have developed an App (the CPC Risk Calculator) that can be used to predict cancer recurrence after surgery for prostate cancer. They have published a description of this App and examples of its utility in an article recently published online in European Urology Focus.
John Leppert, associate professor of urology, and Wendy Fantl, assistant professor of OBGYN, just began their 2 year grant awarded by the Parker Institute of Cancer Immunotherapy, for their project titled "Re-establishing immunotherapy as a first-line treatment for select metastatic renal cell carcinoma patients informed by multiplexed imaging cytometry".
A new study finds that men in North America, Australia and Europe produced less than half as many sperm in 2011 compared with 1973. Equally alarming: The quality was worse. Expert Michael Eisenberg, assistant professor of urology, agrees that the data have some flaws but says it’s enough to justify further investigation.
Dr. Geoff Sonn gave this webinar presentation on "2017 State of the Art Men's Genitourinary Health presentation" which discussed healthy choices for men – including preventative steps, symptoms of prostate disease, and new approaches to prostate cancer screening including non-surgical techniques, using MRI.
Chief Resident Dr. Michael Davenport matched into a Reconstruction Fellowship at UT Southwestern in Dallas, TX with Dr. Allen Morey, that he will begin later next year following graduation.
Minimally Invasive Oncology Fellowship
Following graduation next year, Chief Resident Dr. Harsha Mittakanti will be going to Swedish Hospital in Seattle to begin a Minimally invasive Oncology Fellowship with Dr. Jim Porter.
Urology Graduation Dinner
The Department hosted the Urology Graduation Dinner on June 25, 2017 to honor our graduating residents and fellows:
Residency Program: David Guo, Remy Lamberts, and Dimitar Zlatev
FPMRS Fellowship Program: Amy Dobberfuhl, and Amandeep Mahal
Donna Peehl Retirement Celebration
Richard Fan, PhD, instructor and biomedical engineer in the department of urology, organized the first ever Biodesign Health Technology Showcase, which gathered together students from Stanford Biodesign courses to form teams and present their identifed health care needs and solutions-in-progress.
Newly funded NIH U01 grant
Donna Peehl, professor emerita of urology, received an NIH U01 grant for her project titled "Metabolic Imaging Comparisons of Patient-Derived Models of Renal Cell Carcinoma".
Stanford Urology Alumni Celebration
New book Incontinence 6th Edition released
Philip Hanno, clinical professor of urology, leads the Bladder Pain Syndrome Committee of the International Consultation on Incontience, whose book chapter is included in the new book, Incontinence 6th Edition, which takes on board the outcomes of the 6th International Consultation on Incontinence, held in Tokyo during Steptember 2016. The work is the result of a systematic review and update by two-hundred experts, divided into 23 chapter committees.
New article shows that there are extensive chemical modifications to the DNA of prostate cancers called DNA methylation
The changes are known to affect gene regulation, and we find that genes regulated by a specific protein, called EZH2, are particularly targeted by this chemical modification. Furthermore, these methylation changes, since they are specific for prostate cancer, could form the basis of new tools to diagnose prostate cancer.
AUA 2017 Annual Meeting - Boston
AUA Best Video Award
Drs. Joe Liao and Tim Chang won the AUA Best Video Award for their video entitled "Multimodal Enhanced Cystoscopy for Improved Bladder Tumor Resections" in the Bladder Oncology and Diversion session at the AUA 2017 Annual Meeting in Boston.
In a large study covering 10 institutions across the country, over 1400 men were enrolled with relatively low risk prostate cancer, and watched with PSA testing and periodic biopsies. The study reports that men who are obese have a higher risk for showing more cancer or higher grade cancer when they are biopsied after 1 year of surveillance. Likewise, men who have a relatively small prostate and high PSA (high PSA density) also have a higher risk. These men might need to undergo biopsy sooner when on active surveillance. See article highlight in the accompanying editorial in the Journal of Urology.
Jim Brooks, professor of urology, helped author the article, The Radiogenomic Risk Score: Construction of a Prognostic Quantitative, Noninvasive Image-based Molecular Assay for Renal Cell Carcinoma, which won the 2016 Margulis Award for Scientific Excellence awarded by the Radiological Society of North America earlier this year.
Recent publication "Defining the rate of negative ureteroscopy in the general population treated for upper tract urinary stone disease" featured in Uro Today: Beyond the Abstract.
Michael Eisenberg, assistant professor of urology, says men are underserved when it comes to infertility testing, partly because it's "incorrectly seen as a woman's problem." In 20 to 25 percent of infertility cases, men aren't even evaluated. That could change, Eisenberg said, with home-based testing that made it easier and less anxiety-inducing to analyze a sperm sample.
According to Sandstone consultant and male infertility expert Michael Eisenberg, assistant professor of urology, Trak, an at-home sperm-analysis kit, is a potential game-changer for diagnosing infertility in men.