Archived News & Events
Looking at the safety of Active Surveillance in monitoring patients with prostate cancer
Dr. James Brooks is part of a team of researchers who received funding from the National Institutes of Health to use natural language processing to mine electronic medical records to identify patients with low risk prostate cancer who are managed by Active Surveillance. In Active Surveillance, men with small, low risk cancers are followed with PSA tests, physical examinations and biopsies with the intention that they switch to either surgery or radiation therapy if their cancer becomes more aggressive. Dr. Brooks is part of a national study of Active Surveillance in which they have found that approximately 2/3 of patients have cancers that do not progress and do not need treatment after 5 years of monitoring. Identifying all patients on Active Surveillance at Stanford and elsewhere will allow Dr. Brooks and colleagues to look at the safety of Active Surveillance, understand variations in care patterns (e.g. how often patients get PSA tests and biopsies) and test whether other tests such as prostate MRI scans are helpful in managing patients.
Last week, a new study revealed an alarming drop in sperm counts for men Western countries. Does this mean men are becoming infertile? According to expert Dr. Michael Eisenberg, "it should be seen as a wake-up call, but not necessarily the end of days."
2017 Department of Urology Picnic - SCRA
Dr. James Brooks and collaborators from Denmark have developed an App (the CPC Risk Calculator) that can be used to predict cancer recurrence after surgery for prostate cancer. They have published a description of this App and examples of its utility in an article recently published online in European Urology Focus.
Department of Urology's, John Leppert, MD, and OB/GYN's, Wendy Fantl, PhD, just began their 2 year grant awarded by the Parker Institute of Cancer Immunotherapy, for their project titled "Re-establishing immunotherapy as a first-line treatment for select metastatic renal cell carcinoma patients informed by multiplexed imaging cytometry".
A new study finds that men in North America, Australia and Europe produced less than half as many sperm in 2011 compared with 1973. Equally alarming: The quality was worse. Expert Dr. Michael Eisenberg agrees that the data have some flaws but says it’s enough to justify further investigation.
Donna Peehl Retirement Celebration
Richard Fan, PhD, instructor and biomedical engineer in the department of urology, organized the first ever Biodesign Health Technology Showcase, which gathered together students from Stanford Biodesign courses to form teams and present their identifed health care needs and solutions-in-progress.
Newly funded NIH U01 grant
Dr. Donna Peehl just received an NIH U01 grant for her project titled "Metabolic Imaging Comparisons of Patient-Derived Models of Renal Cell Carcinoma".
Stanford Urology Alumni Celebration
New book Incontinence 6th Edition released
Dr. Philip Hanno leads the Bladder Pain Syndrome Committee of the International Consultation on Incontience, whose book chapter is included in the new book, Incontinence 6th Edition, which takes on board the outcomes of the 6th International Consultation on Incontinence, held in Tokyo during Steptember 2016. The work is the result of a systematic review and update by two-hundred experts, divided into 23 chapter committees.
New article shows that there are extensive chemical modifications to the DNA of prostate cancers called DNA methylation
The changes are known to affect gene regulation, and we find that genes regulated by a specific protein, called EZH2, are particularly targeted by this chemical modification. Furthermore, these methylation changes, since they are specific for prostate cancer, could form the basis of new tools to diagnose prostate cancer.
AUA 2017 Annual Meeting - Boston
In a large study covering 10 institutions across the country, over 1400 men were enrolled with relatively low risk prostate cancer, and watched with PSA testing and periodic biopsies. The study reports that men who are obese have a higher risk for showing more cancer or higher grade cancer when they are biopsied after 1 year of surveillance. Likewise, men who have a relatively small prostate and high PSA (high PSA density) also have a higher risk. These men might need to undergo biopsy sooner when on active surveillance. See article highlight in the accompanying editorial in the Journal of Urology.
Dr. Jim Brooks helped author the article, The Radiogenomic Risk Score: Construction of a Prognostic Quantitative, Noninvasive Image-based Molecular Assay for Renal Cell Carcinoma, which won the 2016 Margulis Award for Scientific Excellence awarded by the Radiological Society of North America earlier this year.
Recent publication "Defining the rate of negative ureteroscopy in the general population treated for upper tract urinary stone disease" featured in Uro Today: Beyond the Abstract.
Dr. Michael Eisenberg, who specializes in male fertility, says men are underserved when it comes to infertility testing, partly because it's "incorrectly seen as a woman's problem." In 20 to 25 percent of infertility cases, men aren't even evaluated. That could change, Eisenberg said, with home-based testing that made it easier and less anxiety-inducing to analyze a sperm sample.
According to Sandstone consultant and male infertility expert Dr. Michael Eisenberg, Trak, an at-home sperm-analysis kit, is a potential game-changer for diagnosing infertility in men.
Important study could lead to a new diagnostic tool that could be used to determine positive surgical margins in almost real time in the operating room
Dr. Geoff Sonn's recent publication in PNAS may enable more accurate diagnosis of prostate cancer by imaging metabolites to offer a rapid, almost real-time diagnosis for men undergoing prostate biopsy.
A new imaging technique, which works on any hollow organ, could help doctors better prepare for surgery
Advanced computer imaging technology has created a three-dimensional computer reconstruction of a patient's bladder. According to Dr. Joseph Liao, these three-dimensional images could help doctors prepare for surgery. “Sometimes you don’t have a sense – where was I in the bladder?” Liao said. Seeing a three-dimensional rendering of an organ before operating, like having a map before embarking on a trip, could make the procedure easier for doctors.
Kidney cancer research paper featured on the cover of Oncotarget
Publication titled "Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer" was published as a priority paper and reviewed in an accompanying editorial in the journal titled "Untangling ccRCC prognosis with SLINKY".
Article on urinary imaging in young infants featured in the preferred literature review of the American Academy of Pediatrics
Publication titled "Urinary Imaging Findings in Young Infants with Bacteremic Urinary Tract Infection" was written up and featured for discussion and CME in the preferred literature review of the American Academy of Pediatrics (AAP).
The study's lead author, Dr. Michael Eisenberg, assistant professor of urology and director of male reproductive medicine and surgery at Stanford, hopes the findings will encourage more men diagnosed with infertility to seek follow-up care.
Dr. Craig Comiter, professor of urology, explains how alcohol suppresses the body’s natural anti-diuretic hormone, leading to frequent urination.
The founding chair of Stanford’s Department of Urology was an investigator for the controversial PSA blood test for prostate cancer, and used basic research in urology and surgery to help patients.