Urology Research Faculty
Professor of Urology
Professor of Developmental Biology
My lab studies the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Professor and Vice-Chair of Urology
Chief of Urologic Oncology
Our interest is in developing diagnostic and prognostic markers for urological diseases. Our work spans discovery, measurement methodologies, and clinical validation of candidate biomarkers. We have primarily used genomic and proteomic approaches for biomarker discovery. While our primary focus has been in prostate cancer, we have also worked in kidney cancer and other malignancies. We are also working to characterize the functional roles of several of the candidate biomarkers in cancer. In the past several years our work has expanded into benign urologic diseases including benign prostatic hyperplasia, obstructive nephropathy, and androgen insensitivity syndrome. In collaboration with bioengineers and radiologists, we have active research in molecular imaging, and protein and nucleotide detection on biological samples. We also participate in several large clinical trials for development, validation and implementation of clinical biomarkers in prostate cancer.
Assistant Professor (Research) of Urology
Wendy’s passion is in the mechanistic understanding of intracellular signaling pathways, DNA damage and the host immune system and their role in malignancies with an “eye on the prize” of a clinically translational endpoint. Her current interests are to apply multi-parametric single-cell technology platforms to identify disease-causing cell subpopulations in ovarian cancer and other malignancies.
Associate Professor of Urology
Director of Urologic Oncology (VAPAHCS)
Our research aims to improve the global quality of care for patients with Urologic Cancer with a particular focus on kidney cancer. We are investigating novel proteomic platforms and assays to diagnose kidney cancer and predict response to therapy. We are evaluating the comparative effectiveness of various kidney cancer surgeries and their impact on chronic kidney disease and its downstream effects. We are applying epidemiology, bioinformatics, and health services methods to urologic conditions.
Professor of Urology
Director of Research
Chief of Urology (VAPAHCS)
The overarching theme of our research is translating molecular diagnostics for urological diseases from bench to bedside. Interfacing biology, engineering, medicine, and surgery, we aim to translate molecular biosensing and imaging technologies to the clinics with the goal of transforming the diagnosis and treatment of urological infections and cancers that are among the most common and expensive human diseases. We are particularly interested in harnessing the diagnostic potentials of urine using ultrasensitive molecular biosensors and incorporating optical and molecular imaging to improve the outcome of cancer surgery (i.e. image-guided surgery). Current projects include development of an integrated biochip for point-of-care diagnosis of urinary tract infections, in vivo microscopy of the urinary tract, and molecular contrast agents for optical imaging of bladder cancer.
Assistant Professor of Urology
My primary interest is in improving prostate cancer diagnosis and treatment through MRI and image-targeted prostate biopsy. In collaboration with radiologists at Stanford, we are working to define the optimal role of MRI in prostate cancer. We hope to improve cancer imaging to the point that some men with elevated PSA may safely avoid prostate biopsy. For those who need biopsy, we are evaluating novel MRI-US fusion targeted biopsy, a technique that greatly improves upon the conventional biopsy method. More accurate prostate biopsy enables better decision making about treatment options such as deciding between active surveillance and surgery.
Moving beyond biopsy, I am interested in the use of imaging to select patients who are candidates for prostate cancer focal therapy. Focal therapy involves ablation of prostate cancers under image guidance without destruction or removal of the normal areas of the prostate and with less damage to important surrounding structures that are important for erectile function and urinary continence.
I am also interested in developing novel molecular imaging techniques such as near infrared fluorescence imaging to improve surgery for prostate and kidney cancer.
Departmental Research Meetings
John Leppert promoted to Professor of Urology & appointed Chief of Urology at the Palo Alto VA Health Care System
The Department of Urology is pleased to announce the promotion of Dr. John Leppert to Professor of Urology in the University Medical Line. Dr. Leppert has been on faculty since he joined us here at Stanford in 2008 and has been full time at the Palo Alto VA Medical Center. Dr. Leppert also was appointed this October as the new Chief of Urology at the Palo Alto VA Health Care System, succeeding Dr. Liao who had successfully led the VA in that position for the past 15 years.
Dr. Leppert has been the leader of our urologic oncology team at the VA, taking on the most complex robotic and open surgeries for kidney, prostate, testis and bladder cancers, along with multidisciplinary surgeries with the general and colorectal surgery teams. He also runs a very successful multidisciplinary urologic oncology clinic along with Dr. Brian Dietrich from medical oncology.
In his research, Dr. Leppert has utilized the detailed VA clinical database to address some key questions in urologic cancer that can only be answered with this type of large population studies. He has focused on understanding predictors of life expectancy in this patient population using both comorbidities and specific lab abnormalities to assist in decision making around treatment of localized prostate cancer. Similarly, he has studied predictors of progression of renal disease following surgery for kidney cancer. He has also developed a very large specimen bank of localized and metastatic kidney cancer and with many collaborators at Stanford have added significantly to our understanding of the behavior of these tumors, the immune microenvironment, and response to specific treatments.
Dr. Leppert has also been a key educator in our department, mentoring a long list of our urology residents and fellows, med students, fellows in nephrology and international scholars. He is one of the most popular teachers and research mentors on our faculty, and prides himself on this reputation.